Nod2 Signaling Adaptor Protein

A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.

Also Known As:

CARD15 Protein; Caspase Recruitment Domain Protein 15; Nucleotide Oligomerization Domain 2 Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Signal Transducing Adaptor Proteins
      - CARD Signaling Adaptor Proteins
        Nod2 Signaling Adaptor Protein: 3
      - Nod Signaling Adaptor Proteins
        Nod2 Signaling Adaptor Protein: 3
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - CARD Signaling Adaptor Proteins
        Nod2 Signaling Adaptor Protein: 3
    - Signal Transducing Adaptor Proteins
      - CARD Signaling Adaptor Proteins
        Nod2 Signaling Adaptor Protein: 3
      - Nod Signaling Adaptor Proteins
        Nod2 Signaling Adaptor Protein: 3
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2514
      - CARD Signaling Adaptor Proteins
        Nod2 Signaling Adaptor Protein: 3
    - NLR Proteins: 1729
      - Nod Signaling Adaptor Proteins
        Nod2 Signaling Adaptor Protein: 3
    - Signal Transducing Adaptor Proteins
      - CARD Signaling Adaptor Proteins
        Nod2 Signaling Adaptor Protein: 3
      - Nod Signaling Adaptor Proteins
        Nod2 Signaling Adaptor Protein: 3

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Disease

Drug/Important Bio-Agent (IBA)